Hypoexpression and Epigenetic Regulation of Candidate Tumor Suppressor Gene CADM-2 in Human Prostate Cancer
نویسندگان
چکیده
منابع مشابه
Hypoexpression and epigenetic regulation of candidate tumor suppressor gene CADM-2 in human prostate cancer.
PURPOSE Cell adhesion molecules (CADM) comprise a newly identified protein family whose functions include cell polarity maintenance and tumor suppression. CADM-1, CADM-3, and CADM-4 have been shown to act as tumor suppressor genes in multiple cancers including prostate cancer. However, CADM-2 expression has not been determined in prostate cancer. EXPERIMENTAL DESIGN The CADM-2 gene was cloned...
متن کاملoexpression and Epigenetic Regulation of Candidate R or Suppressor Gene CADM - 2 in Human Prostate Cancer
Download pose: Cell adhesion molecules (CADM) comprise a newly identified protein family whose funcinclude cell polarity maintenance and tumor suppression. CADM-1, CADM-3, and CADM-4 have shown to act as tumor suppressor genes in multiple cancers including prostate cancer. However, -2 expression has not been determined in prostate cancer. erimental Design: The CADM-2 gene was cloned and charact...
متن کاملANX7, a candidate tumor suppressor gene for prostate cancer.
The ANX7 gene is located on human chromosome 10q21, a site long hypothesized to harbor a tumor suppressor gene(s) (TSG) associated with prostate and other cancers. To test whether ANX7 might be a candidate TSG, we examined the ANX7-dependent suppression of human tumor cell growth, stage-specific ANX7 expression in 301 prostate specimens on a prostate tissue microarray, and loss of heterozygosit...
متن کاملTime dependent of epigenetic effect of disulfiram on tumor suppressor gene of RASSF1A in Hela cancer cell line
Introduction: Cervical cancer is the third most common tumor among women. Surgery, radiotherapy, and chemotherapy are common treatments, however high stage tumors have frequently poor prognosis. Nowadays, the epigenetic reversion introduced as an efficient strategy of treatment of cervical cancer. In the process, inhibitors of DNA methyltransferase (DNMT) induce re-expression of tumor suppresso...
متن کاملEpigenetic regulation of the potential tumor suppressor gene, hLHX6.1, in human cervical cancer.
It is well known that the Homo sapiens LIM homeobox domain 6 gene (hLHX6), a putative transcription regulator, controls the differentiation and development of neural and lymphoid cells, particularly in the central nervous system. In this study, we investigated hLHX6.1 (an isoform of hLHX6), which functions as a tumor suppressor gene in the cervix. Firstly, the methylation levels of the hLHX6 an...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Clinical Cancer Research
سال: 2010
ISSN: 1078-0432,1557-3265
DOI: 10.1158/1078-0432.ccr-10-1461